Effects of CaMKII inhibitor tatCN21 on activity-dependent redistribution of CaMKII in hippocampal neurons.

@article{TaoCheng2013EffectsOC,
  title={Effects of CaMKII inhibitor tatCN21 on activity-dependent redistribution of CaMKII in hippocampal neurons.},
  author={Jung-Hwa Tao-Cheng and Y. Yang and K. Ulrich Bayer and Thomas S. Reese and A Dosemeci},
  journal={Neuroscience},
  year={2013},
  volume={244},
  pages={188-96}
}
TatCN21 is a membrane permeable calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor derived from the inhibitor protein CaMKIIN. TatCN21 has been used to demonstrate the involvement of CaMKII in a variety of physiological and pathological phenomena, and it also limits excitotoxic damage in neurons. Here we use preembedding immunogold electron microscopy to examine the effect of tatCN21 on the redistribution of CaMKII in cultured hippocampal neurons. Incubation of cultures with… CONTINUE READING