Effects of Ca2+ channel blockers on transmitter release and presynaptic currents at the frog neuromuscular junction.

@article{Katz1995EffectsOC,
  title={Effects of Ca2+ channel blockers on transmitter release and presynaptic currents at the frog neuromuscular junction.},
  author={Eleonora Katz and Paola Ferro and Bruce D. Cherksey and Mutsuyuki Sugimori and R R Llin{\'a}s and Osvaldo Daniel Uchitel},
  journal={The Journal of physiology},
  year={1995},
  volume={486 ( Pt 3)},
  pages={695-706}
}
1. The effects of the calcium channel blockers, funnel-web spider toxin (FTX), omega-agatoxin IVA (omega-Aga IVA) and omega-conotoxin GVIA (omega-CgTX), were tested on transmitter release and presynaptic currents in frog motor nerve endings. 2. Evoked transmitter release was blocked by FTX (IC50 = 0.02 microliter ml-1) and omega-CgTX (1 microM) but was not affected by omega-Aga IVA (0.5 microM). When FTX (0.1 microliter ml-1) was assayed on spontaneous release either in normal Ringer solution… CONTINUE READING