Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole

@article{GawroskaSzklarz2010EffectsOC,
  title={Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole},
  author={Barbara Gawrońska-Szklarz and Andrzej Siuda and Mateusz Kurzawski and Dariusz Bielicki and Wojciech Marlicz and Marek Droździk},
  journal={European Journal of Clinical Pharmacology},
  year={2010},
  volume={66},
  pages={681-687}
}
Eradication of H. pylori is an important treatment strategy in peptic ulcer patients. Current regimens of eradication consist of proton pump inhibitor (PPI) and two antibiotics. Effects of PPI may depend on their metabolism, and other factors important for the pathophysiology of peptic ulcer disease. Aim of the present study was to evaluate an association of CYP2C19, MDR1, and IL-1B polymorphisms with the eradication rate of H. pylori in Polish Caucasian patients treated with a triple therapy… CONTINUE READING
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