Effects of CTR4 deletion on virulence and stress response in Cryptococcus neoformans

@article{Zhang2016EffectsOC,
  title={Effects of CTR4 deletion on virulence and stress response in Cryptococcus neoformans},
  author={Ping Zhang and Defa Zhang and Xueru Zhao and Dongsheng Wei and Yu Wang and Xudong Zhu},
  journal={Antonie van Leeuwenhoek},
  year={2016},
  volume={109},
  pages={1081-1090}
}
Roles of the high-affinity copper transporter Ctr4 in the virulence of Cryptococcus neoformans remain to be fully determined. Here we demonstrate that Ctr4 plays a necessary role in virulence and tolerance to a number of stress conditions. We first observed, with the method of flame atomic absorption spectrometry, that deletion of CTR4 resulted in a significant decrease in intracellular copper level, confirming the role of Ctr4 as a copper transporter in C. neoformans. Furthermore, CTR4 was… CONTINUE READING
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