Effects of CP-99, 994, a tachykinin NK(1) receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of NK(1) and 5-HT(3) receptors.

@article{Minami2001EffectsOC,
  title={Effects of CP-99, 994, a tachykinin NK(1) receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of NK(1) and 5-HT(3) receptors.},
  author={Masaru Minami and Toru Endo and Hiroyuki Yokota and Toru Ogawa and Masahiro Nemoto and Naoya Hamaue and Masahiko Hirafuji and Mitsuhiro Yoshioka and Atsushi Nagahisa and Paul L. R. Andrews},
  journal={European journal of pharmacology},
  year={2001},
  volume={428 2},
  pages={
          215-20
        }
}
The effect of CP-99, 994, a tachykinin NK(1) receptor antagonist, on abdominal vagal afferent nerve activity in the ferret was investigated. Substance P (1 microg/kg, i.v.) increased vagal afferent activity by 449.0+/-51.9% and this was reduced to 145.9+/-5.7% (p<0.01) by pre-treatment with CP-99, 994 (1 mg/kg, i.v.), and to 149.5+/-1.5% (p<0.001) by granisetron (1 mg/kg, i.v.), a 5-HT(3) receptor antagonist. In addition, the increase in vagal nerve activity induced by 5-HT (25 microg/kg, i.v… CONTINUE READING
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