Effects of CP-900691, A Novel Peroxisome Proliferator-Activated Receptor α Agonist on Diabetic Nephropathy in the BTBR ob/ob mouse

@inproceedings{Askari2014EffectsOC,
  title={Effects of CP-900691, A Novel Peroxisome Proliferator-Activated Receptor α Agonist on Diabetic Nephropathy in the BTBR ob/ob mouse},
  author={Bardia Askari and T. Wietecha and Kelly L. Hudkins and Edward J Fox and Kevin D O'brien and Jinkyu Kim and Tri Quang Nguyen and Charles E. Alpers},
  booktitle={Laboratory Investigation},
  year={2014}
}
Piperidine-based peroxisome proliferator-activated receptor-α agonists are agents that are efficacious in improving lipid, glycemic, and inflammatory indicators in diabetes and obesity. This study sought to determine whether CP-900691 ((S)-3-[3-(1-carboxy-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid 4-trifluoromethyl-benzyl ester; CP), a member of this novel class of agents, by decreasing plasma triglycerides, could prevent diabetic nephropathy in the Black and Tan, BRachyuric (BTBR… CONTINUE READING
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