Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats.

@article{Przegaliski2005EffectsOC,
  title={Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats.},
  author={Edmund Przegaliński and Małgorzata Filip and Małgorzata Frankowska and Magdalena Zaniewska and Iwona Papla},
  journal={Neuropeptides},
  year={2005},
  volume={39 5},
  pages={525-33}
}
We examined the influence of CP 154,526, a selective antagonist of corticotropin-releasing factor (CRF)1 receptors, in the locomotor, sensitizing, discriminative stimulus and rewarding effects of cocaine, as well as on the cocaine-induced reinstatement of cocaine-seeking behavior in male Wistar rats. CP 154,526 in doses of 5, 10 and 20 mg/kg, which did not affect basal locomotor activity, dose-dependently reduced the hyperactivation evoked by cocaine. To assess the effects of CP 154,526 on the… CONTINUE READING