Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.

@article{Fozard2002EffectsOC,
  title={Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.},
  author={John R. Fozard and Karen M Ellis and Maria F Villela Dantas and Bruno Tigani and Lazzaro Mazzoni},
  journal={European journal of pharmacology},
  year={2002},
  volume={438 3},
  pages={183-8}
}
We have investigated the effect of 2(4-((2-carboxymethyl)phenyl)ethylamino)-5'-N-ethylcarboxamidoadenosine (CGS 21680), a potent and selective agonist at adenosine A2A receptors, on pulmonary inflammation induced by allergen challenge in the ovalbumin-sensitised, Brown Norway rat. Aerosol administration of ovalbumin (5 mg x ml(-1) for 60 min; calculated dose 0.4 mg x kg(-1)) induced increases in bronchoalveolar lavage fluid leukocyte numbers, protein content and myeloperoxidase and eosinophil… CONTINUE READING
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