Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection

@article{Mulherin2003EffectsOC,
  title={Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection},
  author={Stephanie A. Mulherin and T. O'Brien and John P. A. Ioannidis and James J Goedert and Susan P Buchbinder and Roel A. Coutinho and Beth D. Jamieson and Laurence Meyer and Nelson L Michael and Giuseppe Pantaleo and Gian Paolo Rizzardi and Hanneke Schuitemaker and Haynes W. Sheppard and Ioannis D Theodorou and David Vlahov and Philip S. Rosenberg},
  journal={AIDS},
  year={2003},
  volume={17 3},
  pages={377-87}
}
OBJECTIVE To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression. DESIGN Pooled analysis of individual patient data from 10 cohorts of HIV-1 seroconverters from the United States, Europe, and Australia. METHODS We studied HIV-1 seroconverters of European (n = 1635) or African (n = 215) ancestry who had been genotyped for CCR5-Delta32 and CCR2-64I. We used Cox proportional hazards models with time-varying… CONTINUE READING

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