Effects of Butyrate on the Erythropoietin Receptor of Cell Line IW

@inproceedings{Hermine2000EffectsOB,
  title={Effects of Butyrate on the Erythropoietin Receptor of Cell Line IW},
  author={Olivier Hermine and Jie Dong and Eugene Goldwasser},
  year={2000}
}
The murine erythroleukemic cell line, IW201, normally expresses only low-affinity erythropoietin receptors. Exposure of these cells for 48 hours to sodium butyrate results in a change in receptor kd from about 600 pmol/L to 100 to 200 pmol/L. This change in affinity is accompanied by downregulation of both receptor number and receptor mRNA. Cells exposed to sodium butyrate for 2 hours show a similar