Effects of Buprenorphine Maintenance Dose on μ-Opioid Receptor Availability, Plasma Concentrations, and Antagonist Blockade in Heroin-Dependent Volunteers

@article{Greenwald2003EffectsOB,
  title={Effects of Buprenorphine Maintenance Dose on $\mu$-Opioid Receptor Availability, Plasma Concentrations, and Antagonist Blockade in Heroin-Dependent Volunteers},
  author={Mark K. Greenwald and Chris Ellyn Johanson and David E. Moody and James H. Woods and Michael R. Kilbourn and Robert A. Koeppe and Charles Roberts Schuster and Jon-Kar Zubieta},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={2000-2009}
}
The clinical effectiveness of opioid maintenance for heroin dependence is believed to result from a medication's ability to decrease μ-opioid receptor (μOR) availability thereby replacing agonist effects, alleviating withdrawal symptoms and attenuating heroin effects. We empirically tested this hypothesis in five heroin-dependent volunteers who were successively maintained on 32, 16, 2, and 0 mg daily buprenorphine (BUP) tablet doses. We predicted and confirmed that higher BUP doses would… 
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