Effects of Brn-4 on the neuronal differentiation of neural stem cells derived from rat midbrain.

@article{Tan2010EffectsOB,
  title={Effects of Brn-4 on the neuronal differentiation of neural stem cells derived from rat midbrain.},
  author={Xue-Feng Tan and J Qin and G S Jin and Mei-Ling Tian and Hao-Ming Li and Hui-xia Zhu and Xinhua Zhang and Jin-Hong Shi and Zhen Huang},
  journal={Cell biology international},
  year={2010},
  volume={34 9},
  pages={877-82}
}
NSCs (neural stem cells) provide a powerful research tool for the design and discovery of new approaches to cell replacement therapy during brain repair. However, the usefulness of this tool has been particularly obstructed by limited neuronal differentiation of NSCs. Brn-4, a member of the POU domain family of transcription factors, has been previously implicated in the development of neurons by expression analysis. Here, we directly investigated the effects of Brn-4 on the neuronal… CONTINUE READING