Effects of Brimonidine on Retinal Pigment Epithelial Cells and Müller Cells Exposed to Amyloid-Beta 1-42 Peptide In Vitro.

@article{Tsao2018EffectsOB,
  title={Effects of Brimonidine on Retinal Pigment Epithelial Cells and M{\"u}ller Cells Exposed to Amyloid-Beta 1-42 Peptide In Vitro.},
  author={Sean W Tsao and Rami San Gabriel and Kunal H. Thaker and Baruch D. Kuppermann and Maria Cristina Kenney},
  journal={Ophthalmic surgery, lasers & imaging retina},
  year={2018},
  volume={49 10},
  pages={
          S23-S28
        }
}
BACKGROUND AND OBJECTIVE To evaluate whether brimonidine can prevent cytotoxicity in human retinal pigment epithelial (RPE) and Müller (MIO) cells after exposure to amyloid-beta 1-42 (Aβ42). MATERIALS AND METHODS An in vitro model of geographic atrophy (GA), which is an end-stage complication of age-related macular degeneration (AMD), simulated with the application of Aβ42 in cell culture. RPE and MIO cells were pretreated with brimonidine for 6 hours, then exposed to 10μM Aβ42 for 24 hours… CONTINUE READING
BETA
1
Twitter Mention