The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to regulate a number of fundamental vascular functions, such as vascular tone and remodeling processes. The aim of the present thesis was to study the effects of biomechanical forces on the vessel wall. Intact human conduit vessels were exposed to normal or high intraluminal pressure… CONTINUE READING
Figure 3. The distribution of the overlapping genes that responded to both pressure and shear stress. Shaded area indicates genes that responded in the same direction by the two stimuli. Open area indicates genes that are regulated in opposite direction by the two forces. The relative change of expression of the overlapping genes are expressed in percent. 100% indicate a 2-fold increase.