Effects of Barbiturates on Facilitative Glucose Transporters are Pharmacologically Specific and Isoform Selective

@article{Haspel1999EffectsOB,
  title={Effects of Barbiturates on Facilitative Glucose Transporters are Pharmacologically Specific and Isoform Selective},
  author={Howard C. Haspel and K. N. Stephenson and Theresa Davies-Hill and Ahlam A El-Barbary and Jesus. F. Lobo and Richard L Croxen and W. Mougrabi and Ellen M. Koehler-Stec and Joseph D. Fenstermacher and Ian A. Simpson},
  journal={The Journal of Membrane Biology},
  year={1999},
  volume={169},
  pages={45-53}
}
Barbiturates inhibit GLUT-1-mediated glucose transport across the blood-brain barrier, in cultured mammalian cells, and in human erythrocytes. Barbiturates also interact directly with GLUT-1. The hypotheses that this inhibition of glucose transport is (i) selective, preferring barbiturates over halogenated hydrocarbon inhalation anesthetics, and (ii) specific, favoring some GLUT-# isoforms over others were tested. Several oxy- and thio-barbiturates inhibited [3H]-2-deoxyglucose uptake by GLUT-1… CONTINUE READING
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