Effects of Ba2+ and Cs+ on apical membrane K+ conductance in toad retinal pigment epithelium.

@article{Hughes1995EffectsOB,
  title={Effects of Ba2+ and Cs+ on apical membrane K+ conductance in toad retinal pigment epithelium.},
  author={Bret A Hughes and Alison Shaikh and Ateeq Ahmad},
  journal={The American journal of physiology},
  year={1995},
  volume={268 5 Pt 1},
  pages={C1164-72}
}
Intracellular microelectrode techniques were employed to characterize the blocker sensitivity of the K+ conductance (gK) at the apical membrane of the toad retinal pigment epithelium (RPE). Increasing the K+ concentration in the apical bath ([K+]o) from 2 to 5 mM produced a rapid depolarization of the apical membrane potential (VA). The addition of 0.5 mM Ba2+ or 5 mM Cs+ to the apical bath rapidly depolarized VA and increased the transepithelial resistance and ratio of apical-to-basolateral… CONTINUE READING
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