Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice.

@article{Kim1999EffectsOB,
  title={Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice.},
  author={Jee Yae Kim and Se Heon Cho and Youn Woo Kim and Eun Chul Jang and So Young Park and Eun Jin Kim and Seong Kyu Lee},
  journal={Journal of Korean Medical Science},
  year={1999},
  volume={14},
  pages={648 - 652}
}
To investigate whether BCG, lymphtoxin (LT) or bee venom (BV) can prevent insulitis and development of diabetes in non-obese diabetic (NOD) mice, we measured the degree of insulitis and incidence of diabetes in 24 ICR and 96 female NOD mice. NOD mice were randomly assigned to control, BCG-, LT-, and BV-treated groups. The BCG was given once at 6 weeks of age, and LT was given in 3 weekly doses from the age of 4 to 10 weeks. The BV was injected in 2 weekly doses from the age of 4 to 10 weeks… CONTINUE READING

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