Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans

@article{Nunes2016EffectsOA,
  title={Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans},
  author={Amanda A. Nunes and Rafael Guimar{\~a}es dos Santos and Fl{\'a}via de Lima Os{\'o}rio and Rafael F Sanches and Jos{\'e} Alexandre S. Crippa and Jaime E.C. Hallak},
  journal={Journal of Psychoactive Drugs},
  year={2016},
  volume={48},
  pages={195 - 205}
}
Recently, the anti-addictive potential of ayahuasca, a dimethyltryptamine(DMT)- and β-carboline-rich hallucinogenic beverage traditionally used by indigenous groups of the Northwest Amazon and currently by syncretic churches worldwide, has received increased attention. [...] Key Method To better evaluate this topic, we performed a systematic literature review using the PubMed database to find quantitative studies (using statistical analysis) that assessed the effects of ayahuasca or its components in drug…Expand
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The pharmacological mechanisms for the putative reduction in recidivism to alcohol and cocaine misuse are suggested and inhibition of dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) and the dopamine transporter is suggested. Expand
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