• Corpus ID: 19023974

Effects of Aqueous Seed Extract of Persea americana Mill . ( Avocado ) on Blood Pressure and Lipid Profile in Hypertensive Rats

@inproceedings{Imafidon2013EffectsOA,
  title={Effects of Aqueous Seed Extract of Persea americana Mill . ( Avocado ) on Blood Pressure and Lipid Profile in Hypertensive Rats},
  author={Kate Evbu Imafidon and F. C. Amaechina},
  year={2013}
}

• K. E. Imafidon, F. Amaechina
• Published 2013

The effects of aqueous seed extract of Persea americana Mill. (avocado), var. Fuerte, on blood pressures, plasma and tissue lipids of albino rats were investigated. Twenty-five rats were divided into 5 groups of 5 rats each. Group 1 (normal), group 2 (hypertensive), group 3 (hypertensive + 200 mg/kg b .wt of extract), group 4 (hypertensive + 500 mg/kg b. wt of extract) and group 5 (hypertensive + 700 mg/kg b. wt of extract). Except for group 1, which received 100% growers mash, all other groups received 92% growers mash and 8% NaCl as their daily meal for 4 weeks. The different dose of P. americana aqueous extract, significantly (P<0.05) reduced blood pressures of the hypertensive rats. Reduction in total cholesterol, LDL and triacylglycerol levels were observed at the 500 mg/kg b. wt of seed extract in the plasma, kidney, liver and heart. These results suggest that the use of aqueous seed extract of this plant in the treatment of hypertension may produce a favourable lipid profile at the 500 mg/kg dose level.