Corpus ID: 25182652

Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation of OC2 human oral cancer cells.

  title={Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation of OC2 human oral cancer cells.},
  author={Chorng-Chih Huang and He-Hsiung Cheng and Jue-Long Wang and Jin‐Shiung Cheng and Kuo-Liang Chai and Yi-Chien Fang and Chun-Chi Kuo and S. T. Chu and C M Ho and K L Lin and Jeng-Yu Tsai and C-R Jan},
  journal={The Chinese journal of physiology},
  volume={52 3},
The effect of Antrodia camphorata (AC) on human oral cancer cells has not been explored. This study examined the effect of AC on the viability, apoptosis, mitogen-activated protein kinases (MAPKs) phosphorylation and Ca2+ regulation of OC2 human oral cancer cells. AC at a concentration of 25 microM induced an increase in cell viability, but AC at concentrations > or = 50 microg/ml decreased viability in a concentration-dependent manner. AC at concentrations of 100-200 microg/ml induced… Expand
Antrodia camphorata grown on germinated brown rice inhibits HT-29 human colon carcinoma proliferation through inducing G0/G1 phase arrest and apoptosis by targeting the β-catenin signaling.
It is found that the inhibitory efficacy of CBR 80% ethanol (EtOH) extract on HT-29 and CT-26 cell proliferation was more effective than ordinary AC EtOH 80% extract and data suggest that CBR might be useful as a chemopreventive agent against colorectal cancer. Expand
Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells.
Collectively, in PC3 human prostate cancer cells, BayK 8644 induced a [Ca²⁺]i rise by evoking phospholipase C-independent Ca�⁺ release from the endoplasmic reticulum and Ca²¬⁺ entry via protein kinases C-sensitive store-operated Ca²⁻ channels (and/or T-type Ca²⩽⁺ channels). Expand
Role of JNK signaling in oral cancer: A mini review
  • I. Gkouveris, N. Nikitakis
  • Biology, Medicine
  • Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 2017
Understanding the complexity of JNK signaling has the potential to elucidate important molecular aspects of oral cancer, possibly leading to development of novel and individualized therapeutic strategies. Expand
Identification and Isolation of an Intermediate Metabolite with Dual Antioxidant and Anti-Proliferative Activity Present in the Fungus Antrodia cinnamomea Cultured on an Alternative Medium with Cinnamomum kanehirai Leaf Extract
The fungus Antrodia cinnamomea cultured on KLEE exhibited specific anti-proliferative activity against a non-small-cell lung cancer cell line (A549) by Annexin V assay, and a secondary metabolite present in the extract (MEAC-KLEE) exhibited moderate antioxidant activity against DPPH radicals and reducing power, and also induced apoptosis in A549 cells. Expand
Involvement of ERK phosphorylation in the prevention of ischemia-induced ovarian follicular depletion by stem cells.
The results suggest that stem cells might be helpful for ovarian regeneration after injuries by promoting vascular neogenesis and steroidogenesis through the MAPK pathway. Expand
Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata
This article summarizes the recent advances in research on the multifarious pharmacological effects of A. camphorata and aims to provide a reference for further development and utilization of this highly prized mushroom. Expand


Induction of Apoptosis by Antrodia camphorata in Human Premyelocytic Leukemia HL-60 Cells
The data suggest that A. camphorata exerts antiproliferative action and growth inhibition on HL-60 cells through apoptosis induction and that it may have anticancer properties valuable for application in drug products. Expand
Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-κB pathway
Antrodia camphorata (A. camphorata), well known in Taiwan as a traditional Chinese medicine, has been shown to exhibit antioxidant and anticancer effects. In the present study, therefore, we haveExpand
Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis.
Using serum deprivation-induced apoptosis in neuronal-like PC12 cells as a cell stress model, it is found that A. camphorata is effective in preventing serum-deprived apoptosis through a PKA/CREB-dependent pathway. Expand
Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.
Treatment with EAC decreased the cell growth and induced apoptosis both in Hep G2 and PLC/PRF/5 cells. Expand
The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway.
The results suggest that B85 produced strongest vasorelaxation in aortic preparations among five test strains, and the presence of adenosine could possibly be involved in the endothelium-dependent pathway of B85-induced vasoreLaxation. Expand
Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors.
The protective effect of A. cinnamomea is owed to its active component, ADO, which acts through activation of A(2A)-R to prevent serum deprivation-induced PC12 cell apoptosis. Expand
Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture.
Results indicated that MEM induced HepG2 apoptosis through activation of caspase-3 and -8 cascades and regulation of the cell cycle progression to inhibit hepatoma cells proliferation. Expand
Antioxidative and hepatoprotective effects of Antrodia camphorata extract.
Results suggest that A. camphorata extract exerts effective protection against chronic chemical-induced hepatic injury in vivo, by mediating antioxidative and free radical scavenging activities. Expand
Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway.
It is demonstrated that MEM induces HepG2 apoptosis through inhibition of cell growth and up-regulation of Fas/FasL to activate the pathway of caspase-3 and -8 cascades and demonstrates the antiproliferative effect and mechanism of methanol extracts of mycelia form Antrodia camphorata. Expand
Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action.
It is suggested that AC-PS elicit its anti-tumor effect by promoting a Th1-dominant state and killer activities. Expand