Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures.

@article{Pekthong2009EffectsOA,
  title={Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures.},
  author={Dumrongsak Pekthong and Nad{\`e}ge Blanchard and Catherine Abadie and Alexandre Bonet and Bruno Heyd and Georges Mantion and Alain Berthelot and Lysiane Richert and H{\'e}l{\`e}ne Martin},
  journal={Chemico-biological interactions},
  year={2009},
  volume={179 2-3},
  pages={247-55}
}
The expression of cytochrome P450 (CYP) is regulated by both endogenous factors and foreign compounds including drugs and natural compounds such as herbs. When herbs are co-administrated with a given drug in modern medicine it can lead to drug-herb interaction that can be clinically significant. The ability of Andrographis paniculata extract (APE) and Andrographolide (AND), the most medicinally active phytochemical in the extract, to modulate hepatic CYP expression was examined in vivo in rats… CONTINUE READING

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