Effects of Amlodipine, Captopril, and Bezafibrate on Oxidative Milieu in Rats with Fatty Liver

@article{Ackerman2008EffectsOA,
  title={Effects of Amlodipine, Captopril, and Bezafibrate on Oxidative Milieu in Rats with Fatty Liver},
  author={Zvi Ackerman and Mor Oron-Herman and Talma Rosenthal and Orit Pappo and Gabriela Link and Ben-ami Sela and Maria Grozovski},
  journal={Digestive Diseases and Sciences},
  year={2008},
  volume={53},
  pages={777-784}
}
Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in α-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and… 

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