Effects of Amantadine on Dopaminergic Neurons in Discrete Regions of the Rat Brain

@article{Toide1990EffectsOA,
  title={Effects of Amantadine on Dopaminergic Neurons in Discrete Regions of the Rat Brain},
  author={Katsuo Toide},
  journal={Pharmaceutical Research},
  year={1990},
  volume={7},
  pages={670-672}
}
The effect of a dopamine agonist, amantadine, on dopaminergic neurons was investigated in rat brains. Amantadine (40 mg/kg, i.p.) tended to increase DA (16%) and DOPAC (24%) levels. Further, amantadine (40 mg/kg, i.p.) significantly increased HVA levels in frontal cortex (44% above baseline after 40 mg/kg, i.p.) but not in corpus striatum and nucleus… CONTINUE READING