Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na+ Channels

@article{Shiraishi2004EffectsOA,
  title={Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na+ Channels},
  author={M. Shiraishi and R. A. Harris},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={309},
  pages={987 - 994}
}
  • M. Shiraishi, R. A. Harris
  • Published 2004
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Voltage-gated Na+ channels (Na+ channels) mediate the rising phase of action potentials in neurons and excitable cells. Nine subtypes of the α subunit (Nav1.1-Nav1.9) have been shown to form functional Na+ channels to date. Recently, anesthetic concentrations of volatile anesthetics and ethanol were reported to inhibit Na+ channel functions, but it is not known whether all subtypes are inhibited by anesthetics. To investigate possible subtype-specific effects of anesthetics on Na+ channels… CONTINUE READING
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