Effects of Alcohol on Human Carboxylesterase Drug Metabolism

@article{Parker2014EffectsOA,
  title={Effects of Alcohol on Human Carboxylesterase Drug Metabolism},
  author={R. B. Parker and Zhe-yi Hu and B. Meibohm and S. Laizure},
  journal={Clinical Pharmacokinetics},
  year={2014},
  volume={54},
  pages={627-638}
}
Background and ObjectiveHuman carboxylesterase-1 (CES1) and human carboxylesterase-2 (CES2) play an important role in metabolizing many medications. Alcohol is a known inhibitor of these enzymes but the relative effect on CES1 and CES2 is unknown. The aim of this study was to determine the impact of alcohol on the metabolism of specific probes for CES1 (oseltamivir) and CES2 (aspirin).MethodsThe effect of alcohol on CES1- and CES2-mediated probe drug hydrolysis was determined in vitro using… Expand
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TLDR
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TLDR
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