Effects of Akt signaling on nuclear reprogramming.

  title={Effects of Akt signaling on nuclear reprogramming.},
  author={Toshinobu Nakamura and Kimiko Inoue and Shoko Ogawa and Hiroki Umehara and Narumi Ogonuki and Hiromi Miki and Tohru Kimura and Atsuo Ogura and Toru Nakano},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={13 12},
Reprogramming of the epigenetic state from differentiated to pluripotent cells can be attained by cell fusion of differentiated somatic cells with embryonic stem (ES) cells or transfer of the nucleus of a differentiated cell into an enucleated oocyte. Activation of Akt signaling is sufficient to maintain pluripotency of ES cells and promotes derivation of… CONTINUE READING