Effects of Acute and Subchronic Administration of Dexefaroxan , an 2-Adrenoceptor Antagonist , on Memory Performance in Young Adult and Aged Rodents

@inproceedings{Chopin2002EffectsOA,
  title={Effects of Acute and Subchronic Administration of Dexefaroxan , an 2-Adrenoceptor Antagonist , on Memory Performance in Young Adult and Aged Rodents},
  author={Philippe Chopin and F. C. Colpaert and Marc Marien},
  year={2002}
}
The present study examined the influence of dexefaroxan, a potent and selective 2-adrenoceptor antagonist, on cognitive performance in rodents. In young adult rats, dexefaroxan reversed the deficits induced by UK 14304 [5-bromo-N-(4,5dihydro-1-H-imidazol-2-yl)-6-quinoxalinamine], scopolamine, and diazepam in a passive avoidance task. In this test, dexefaroxan also attenuated the spontaneous forgetting induced by a 15-week training-testing interval. Moreover, dexefaroxan, given immediately after… CONTINUE READING