Effects of Acute and Repeated Administration of Amisulpride , a Dopamine D 2 / D 3 Receptor Antagonist , on the Electrical Activity of Midbrain Dopaminergic Neurons 1

@inproceedings{Giovanni1998EffectsOA,
  title={Effects of Acute and Repeated Administration of Amisulpride , a Dopamine D 2 / D 3 Receptor Antagonist , on the Electrical Activity of Midbrain Dopaminergic Neurons 1},
  author={Giuseppe Di Giovanni and Michele Di Mascio and Vincenzo Di Matteo and Ennio Esposito},
  year={1998}
}
Electrophysiological techniques were used to study the effects of amisulpride, a D2/D3 dopamine receptor blocker, on the activity of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA). Administration of single bolus doses of amisulpride (8–32 mg/kg i.v.) induced a dose-dependent increase in the basal activity of dopaminergic neurons, in both the SNc and the VTA. The effect of amisulpride was more evident in the VTA, where it elicited a maximal… CONTINUE READING
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