Effects of Acute Respiratory and Metabolic Acidosis on Diaphragm Muscle Obtained from Rats

@article{Michelet2015EffectsOA,
  title={Effects of Acute Respiratory and Metabolic Acidosis on Diaphragm Muscle Obtained from Rats},
  author={Pierre Michelet and Serge Carreira and Alexandre Demoule and Julien Amour and Olivier Langeron and Bruno Riou and Catherine Coirault},
  journal={Anesthesiology},
  year={2015},
  volume={122},
  pages={876–883}
}
Background:Acute respiratory acidosis is associated with alterations in diaphragm performance. The authors compared the effects of respiratory acidosis and metabolic acidosis in the rat diaphragm in vitro. Methods:Diaphragmatic strips were stimulated in vitro, and mechanical and energetic variables were measured, cross-bridge kinetics calculated, and the effects of fatigue evaluated. An extracellular pH of 7.00 was obtained by increasing carbon dioxide tension (from 25 to 104 mmHg) in the… 
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References

SHOWING 1-10 OF 45 REFERENCES
The effect of respiratory and lactic acidosis on diaphragm function.
TLDR
The changes with respiratory acidosis were similar to those seen with diaphragmatic fatigue and had similar relaxation rate changes, suggesting that intracellular pH may play a mechanistic role in respiratory muscle fatigue.
Lactic acidosis and diaphragmatic function in vitro.
TLDR
The data suggest that physiologic levels of exogenous hydrogen ions are not a primary cause of in vitro diaphragm fatigue, and hydrogen ion and lactic acid concentrations similar to those seen in arterial blood at maximal exercise decrease contractility of the in vitro isolated rat diphragm.
Effects of uncompensated and compensated metabolic acidosis on canine diaphragm.
TLDR
Detailed qualitative results were observed during spontaneous inspiratory efforts where Pdi was compared at constant magnitudes of diaphragmatic electromyograms, and Twitch characteristics revealed that metabolic acidosis led to a significant shortening of twitch relaxation time and compensated acidosis added to this effect a significant decrease in twitch amplitude.
Alteration of the Piglet Diaphragm Contractility In Vivo and Its Recovery after Acute Hypercapnia
TLDR
A short exposure to respiratory acidosis decreased diaphragmatic contractility proportionally to the degree of hypercapnia, and this alteration was only partially reversed at 60 min after exposure.
Interaction of Metabolic and Respiratory Acidosis with &agr; and &bgr;-adrenoceptor Stimulation in Rat Myocardium
TLDR
Acute metabolic and respiratory acidosis induce different myocardial effects related to different decreases in intracellular pH, and only metabolic acidosis impairs the positive inotropic effect of &bgr;-adrenergic stimulation.
Hypoxic, hypercapnic acidosis decreases tension and increases fatigue in hamster diaphragm muscle in vitro.
  • S. Esau
  • Biology
    The American review of respiratory disease
  • 1989
TLDR
It is suggested that hypoxic, hypercapnic acidosis has a greater detrimental effect on the muscle than either abnormality alone and makes the muscle more susceptible to fatigue.
Effect of hypercapnia on maximal voluntary ventilation and diaphragm fatigue in normal humans.
TLDR
Diaphragm strength was assessed before and at 0, 20, 40, 60, and 90 min after the MVV in both studies with the subjects breathing air and there was no difference in the level of ventilation for each run.
Effect of carbon dioxide on diaphragmatic function in human beings.
TLDR
It is shown that acute respiratory acidosis equivalent to an arterial carbon dioxide tension of about 54 mm Hg decreases the contractility and endurance time of the diaphragm in human beings.
Size and composition changes in diaphragmatic fibers in rats exposed to chronic hypercapnia.
TLDR
By increasing the ratio of fatigue-resistant fibers, the diaphragm was able to adapt to a sustained load induced by hypercapnia, however, this adaptive process was accompanied by a degenerative change in the tissue.
Moderate and prolonged hypercapnic acidosis may protect against ventilator-induced diaphragmatic dysfunction in healthy piglet: an in vivo study
TLDR
Moderate and prolonged hypercapnic acidosis limited the occurrence of VIDD during controlled mechanical ventilation in a healthy piglet model and was well tolerated during the study period.
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