Effects of Acute Oral Naltrexone on the Subjective and Physiological Effects of Oral D-Amphetamine and Smoked Cocaine in Cocaine Abusers

  title={Effects of Acute Oral Naltrexone on the Subjective and Physiological Effects of Oral D-Amphetamine and Smoked Cocaine in Cocaine Abusers},
  author={S. Comer and S. Mogali and P. Saccone and Paula Askalsky and D. Mart{\'i}nez and E. Walker and J. Jones and S. Vosburg and Z. Cooper and P. Roux and M. Sullivan and J. Manubay and E. Rubin and A. Pines and Emily L Berkower and M. Haney and R. Foltin},
  • S. Comer, S. Mogali, +14 authors R. Foltin
  • Published 2013
  • Medicine
  • Neuropsychopharmacology
  • Despite the prevalent worldwide abuse of stimulants, such as amphetamines and cocaine, no medications are currently approved for treating this serious public health problem. Both preclinical and clinical studies suggest that the opioid antagonist naltrexone (NTX) is effective in reducing the abuse liability of amphetamine, raising the question of whether similar positive findings would be obtained for cocaine. The purpose of this study was to evaluate the ability of oral NTX to alter the… CONTINUE READING
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