Effects of Abeta1-42 fibrils and of the tetrapeptide Pr-IIGL on the phosphorylation state of the tau-protein and on the alpha7 nicotinic acetylcholine receptor in vitro.

@article{Lain2005EffectsOA,
  title={Effects of Abeta1-42 fibrils and of the tetrapeptide Pr-IIGL on the phosphorylation state of the tau-protein and on the alpha7 nicotinic acetylcholine receptor in vitro.},
  author={Enzo Lain and Botond Penke and Andr{\'e} Delacourte and Daniela Guendisch and Hannsj{\"o}rg Schr{\"o}der and Brigitte Witter},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 4},
  pages={879-88}
}
In order to investigate the possible links connecting beta-amyloid (Abeta) accumulation, tau-hyperphosphorylation and nicotinic receptor expression, rat embryonic primary hippocampal cultures were incubated with amyloidogenic peptides. Exposure to 0.5 microm fibrillar Abeta(1-42) for 3 days caused retraction of dendrites, shrinkage of cell bodies and a decrease in the expression of microtubule-associated proteins 2b (MAP2b), without affecting the total number of neurons and their viability. No… CONTINUE READING

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Mentioned Connections BETA
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
GlycineNo subtypeLeucine
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
LeucineNo subtypeGlycine
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
Upon incubation with the putatively protective tetrapeptide propionyl - isoleucine - isoleucine - glycine - leucine ( Pr - IIGL ) , an analogue of the region [ 31 - 34 ] of Abeta , cell bodies were swollen in the region of the apical dendrite .
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