Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.

@article{Nakaya1991EffectsOA,
  title={Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.},
  author={Haruaki Nakaya and Yasunori Takeda and Noritsugu Tohse and Morio Kanno},
  journal={British journal of pharmacology},
  year={1991},
  volume={103 1},
  pages={1019-26}
}
1. In order to determine whether activation of adenosine triphosphate (ATP)-sensitive K+ channels exclusively explains the hypoxia- and ischaemia-induced action potential shortening, effects of tolbutamide and glibenclamide on changes in action potential duration (APD) during hypoxia, metabolic blockade or experimental ischaemia were examined in guinea-pig and canine isolated myocardium by standard microelectrode techniques. 2. With use of patch clamp techniques, activity of ATP-sensitive K… CONTINUE READING

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