Effects of APOE on brain white matter microstructure in healthy adults.

@article{Westlye2012EffectsOA,
  title={Effects of APOE on brain white matter microstructure in healthy adults.},
  author={Lars T. Westlye and Ivar Reinvang and Helge Rootwelt and Thomas Espeseth},
  journal={Neurology},
  year={2012},
  volume={79 19},
  pages={1961-9}
}
OBJECTIVES APOE is related to cholesterol transport and clearance and brain white matter (WM) properties involving myelin, of which cholesterol is a major component. Diffusion tensor imaging enables in vivo investigations of brain WM, and could increase our understanding of the pathways leading to Alzheimer disease. The main objective was to investigate the association between APOE and diffusion tensor imaging-derived indices of WM microstructure. METHODS Healthy participants were assessed on… CONTINUE READING

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