Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression.

@article{Chabrashvili2003EffectsOA,
  title={Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression.},
  author={T. Chabrashvili and C. Kitiyakara and J. Blau and Alex Karber and S. Aslam and W. Welch and C. Wilcox},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2003},
  volume={285 1},
  pages={
          R117-24
        }
}
Oxidative stress accompanies angiotensin (ANG) II infusion, but the role of ANG type 1 vs. type 2 receptors (AT1-R and AT2-R, respectively) is unknown. We infused ANG II subcutaneously in rats for 1 wk. Excretion of 8-isoprostaglandin F2alpha (8-Iso) and malonyldialdehyde (MDA) were related to renal cortical mRNA abundance for subunits of NADPH oxidase and superoxide dismutases (SODs) using real-time PCR. Subsets of ANG II-infused rats were given the AT1-R antagonist candesartan cilexetil (Cand… Expand
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