Effects of AG490 on lens epithelial cell death induced by H2O2

@article{Kim2009EffectsOA,
  title={Effects of AG490 on lens epithelial cell death induced by H2O2},
  author={Ungsoo Samuel Kim and Sang-Min Nam and Sun-ah Jung and Sung Joo Kim and Joon Hyop Lee},
  journal={Japanese Journal of Ophthalmology},
  year={2009},
  volume={54},
  pages={151-155}
}
PurposeTo evaluate the influence of H2O2 on lens epithelial cells (LECs) and to determine the effect of the Janus kinase (JAK) inhibitor AG490 and the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor U0126 on LEC death after H2O2 exposure.MethodsHuman lens epithelial (HLE) B-3 cells were cultured. Cells were treated for 45 min with H2O2 and signal transducers and activators transcription (STAT) 3, JAK2, and ERK1/2 phosphorylation were… CONTINUE READING
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