• Biology, Medicine
  • Published in Journal of immunology 1987

Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and basophils.

@article{Saito1987EffectsOA,
  title={Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and basophils.},
  author={Haruo Saito and Fumikazu Okajima and Thaddeus F.P. Molski and Ramadan I. Sha'afi and Michio Ui and T Ishizaka},
  journal={Journal of immunology},
  year={1987},
  volume={138 11},
  pages={
          3927-34
        }
}
Pretreatment of rat peritoneal mast cells, human basophils, bone marrow-derived mouse mast cells (BMMC) and mouse mast cell line PT-18 cells with 1 microgram/ml pertussis toxin (PT) failed to inhibit immunoglobulin E (IgE)-dependent histamine release from the cells. In BMMC and PT-18 cells, even 20-hr incubation of the cells with 1 microgram/ml PT, which ADP-ribosylates more than 97% of 41 kDa, alpha-subunit of Ni in the cells, failed to affect the IgE-dependent release of histamine or… CONTINUE READING

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