Effects of ACTH and cortisol administration on blood pressure, electrolyte metabolism, atrial natriuretic peptide and renal function in normal man.

@article{Connell1987EffectsOA,
  title={Effects of ACTH and cortisol administration on blood pressure, electrolyte metabolism, atrial natriuretic peptide and renal function in normal man.},
  author={John M. Connell and Judith Ann Whitworth and David L. Davies and Anthony F. Lever and Arthur Mark Richards and Robert Fraser},
  journal={Journal of hypertension},
  year={1987},
  volume={5 4},
  pages={425-33}
}
Both Adrenocorticotrophin (ACTH) and glucocorticoids raise blood pressure in man and animals, but the relationship of this and altered renal function to other cardiovascular variables, and the differences and similarities of the effects of the two agonists have not been fully explained. The present study compares the effects of ACTH (0.5 mg i.m; every 12 h) and cortisol (50 mg orally, every 6 h) in six normal men over a period of 5 days, preceded and followed by control periods of 3 and 2 days… CONTINUE READING