Effects of ACE inhibitors on cardiac angiotensin II and aldosterone in humans: "Relevance of lipophilicity and affinity for ACE".

@article{Ruzicka2010EffectsOA,
  title={Effects of ACE inhibitors on cardiac angiotensin II and aldosterone in humans: "Relevance of lipophilicity and affinity for ACE".},
  author={Marcel Ruzicka and Elizabeth Coletta and Roselyn A White and Ross Davies and Haissam A Haddad and Frans H H Leenen},
  journal={American journal of hypertension},
  year={2010},
  volume={23 11},
  pages={1179-82}
}
BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors differ in their lipophilic/hydrophilic index that determines their tissue bioavailability and affinity to ACE, which may result in major differences in the degree of blockade of cardiac ACE. We evaluated the hypothesis that in patients with chronic heart failure (CHF) and activated cardiac renin… CONTINUE READING