Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury

  title={Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury},
  author={Deborah R. Boone and J. M. Leek and M. Falduto and Karen E. O. Torres and S. L. Sell and M. Parsley and Jeremy C. Cowart and T. Uchida and M. Micci and D. Dewitt and D. Prough and H. Hellmich},
  journal={PLoS ONE},
Virally mediated RNA interference (RNAi) to knock down injury-induced genes could improve functional outcome after traumatic brain injury (TBI); however, little is known about the consequences of gene knockdown on downstream cell signaling pathways and how RNAi influences neurodegeneration and behavior. Here, we assessed the effects of adeno-associated virus (AAV) siRNA vectors that target two genes with opposing roles in TBI pathogenesis: the allegedly detrimental neuronal nitric oxide… Expand
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