Effects of A1 adenosine receptor blockade by bamiphylline on ischaemic preconditioning during coronary angioplasty.

@article{Tomai1996EffectsOA,
  title={Effects of A1 adenosine receptor blockade by bamiphylline on ischaemic preconditioning during coronary angioplasty.},
  author={Fabrizio Tomai and Filippo Crea and Achille Gaspardone and Francesco Versaci and Ruggero de Paulis and Patrizio Polisca and Luigi Chiariello and Pier Agostino Gioffr{\`e}},
  journal={European heart journal},
  year={1996},
  volume={17 6},
  pages={846-53}
}
OBJECTIVE The role of A1 adenosine receptors in preconditioning in humans is unknown. To establish whether bamiphylline, a selective antagonist of A1 adenosine receptors, abolishes ischaemic preconditioning in man, 36 consecutive patients undergoing single-vessel coronary angioplasty were randomized to receive intravenous infusion of bamiphylline (5 mg.kg-1) or placebo (0.9% NaCl) immediately prior to the procedure. DESIGN The mean values (+/- 1 SD) of ST segment shifts on the surface and… CONTINUE READING

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