Corpus ID: 40493915

Effects of A-methopterin (4-amino-N10-methylpteroylglutamic acid) on the synthesis of the adenine moiety of adenosine triphosphate.

@article{Skipper1952EffectsOA,
  title={Effects of A-methopterin (4-amino-N10-methylpteroylglutamic acid) on the synthesis of the adenine moiety of adenosine triphosphate.},
  author={Howard E. Skipper and C Morgan and Leonard L. Bennett},
  journal={Cancer research},
  year={1952},
  volume={12 6},
  pages={
          413-4
        }
}
Summary It has been demonstrated that formate and glycine are effective precursors of ATP adenine and that A-methopterin inhibits the synthesis of this nucleotide. 
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5 Citations

5 Citations

Citation Type

Citation Type

Chromatographic studies of purine metabolism. II. The mechanism of E. coli inhibition by A-methopterin.
Abstract The observed effect of A-methopterin upon Escherichia coli metabolism has been the intracellular accumulation of 5-amino-4-imidazole-carboxamide ribotide, with the concomitant exclusion of… Expand
The effects of gamma-irradiation and of aminopterin on the metabolism of formate-C14, glycine-2-C14, and adenine-8-C14 by chick embryos.
TLDR
Chick embryos were chosen for the experiments to compare the immediate effects of irradiation on nucleic acid synthesis in chick embryos and the studies of Naber and coworkers indicate that aminopterin exerts a toxicity on chick embryos which may be reversed by a combination of purine riboside and thymidine. Expand
Renewal of nucleotides and nucleic acids in C57 mice studied with adenine-4, 6-14C1.
TLDR
Evidence is presented that soluble adenine nucleotides serve as precursors for RNA and DNA, and that the equilibration of nucleotide with RNA is relatively rapid in large and small intestines and probably also in bone marrow. Expand
Concerning the metabolism of adenine by the rat.
Abstract Radioactive adenine has been injected into white male rats and the distribution of radioactivity in the acid-soluble nucleotide fractions of various organs has been examined.
Studies on the metabolism of 4-amino-5-imidazolecarboxamide in vitro. II. Utilization by actively growing tissues.
  • Z. Miller
  • Medicine, Chemistry
  • The Journal of biological chemistry
  • 1957