Effects of 8-bromo cyclic GMP and verapamil on depolarization-evoked Ca2+ signal and contraction in rat aorta.

@article{Salomone1995EffectsO8,
  title={Effects of 8-bromo cyclic GMP and verapamil on depolarization-evoked Ca2+ signal and contraction in rat aorta.},
  author={Salvatore Salomone and Nicole Morel and Th{\'e}ophile Godfraind},
  journal={British journal of pharmacology},
  year={1995},
  volume={114 8},
  pages={
          1731-7
        }
}
1. The pharmacological action of NO donors is usually attributed to a cellular rise in guanosine 3':5'-cyclic monophosphate (cyclic GMP), but this hypothesis is based only on indirect evidence. Therefore, we have studied the effects of cyclic GMP on Ca2+ movements and contraction in rat isolated endothelium-denuded aorta stimulated by KCl depolarizing solution using the permeant analogue 8-bromo cyclic GMP (BrcGMP). Isometric contraction and fura-2 Ca2+ signals were measured simultaneously in… CONTINUE READING
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