Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey

@article{Tani2005EffectsO6,
  title={Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey},
  author={Yoshihiro Tani and Takafumi Ishihara and Tadashi Kanai and Tomochika Ohno and Jesper L. R. Andersson and A. Lilja and Gunnar Antoni and Karl Johan Fasth and Peter Bjurling and G{\"o}ran Westerberg and Per Hartvig and Hirotaka Onoe and Y. Watanabe and Bengt L{\aa}ngstr{\"o}m},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={102},
  pages={189-208}
}
The effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) on the central cholinergic and dopaminergic systems in the Rhesus monkey brain were investigated by positron emission tomography (PET) with the muscarinic cholinergic receptor ligands (N-[11C]methyl-benztropine) and dopaminergic receptor ligands selective for D1 D2, and D3 subtypes ([11C]SCH23390, N-[11C]methyl-spiperone, and (+)[11C]UH232, respectively). None of the doses (3, 10, and 30 mg/kg i.v.) of R-THBP used significantly… Expand
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