Effects of 6-hydroxydopamine lesions of the nigrostriatal pathway on striatal serotonin innervation in adult rats.

@article{Takeuchi1991EffectsO6,
  title={Effects of 6-hydroxydopamine lesions of the nigrostriatal pathway on striatal serotonin innervation in adult rats.},
  author={Yoshiki Takeuchi and Tohru Sawada and Stavia B Blunt and P Feroz Jenner and C. David Marsden},
  journal={Brain research},
  year={1991},
  volume={562 2},
  pages={301-5}
}
The effects of 6-hydroxydopamine lesions of the nigrostriatal pathway on striatal serotonin (5-HT) innervation have been examined using immunohistochemistry in adult rats. One day after lesioning, a large number of swollen and densely stained 5-HT-immunoreactive fibers appeared around the lesion which was almost completely void of 5-HT-immunoreactivity. Four weeks after lesioning, a significant reduction in 5-HT innervation density was verified in the ventral portion of the rostral neostriatum… CONTINUE READING

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