Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).

@article{DAncona1986EffectsO6,
  title={Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).},
  author={Silvia D'Ancona and Gianna Magnolfi and Giovanni Matteo Guidetti and Giuseppe Toffoli and Annaluisa Fantola Lazzarini and Mar{\'i}a Victoria Carrara and Michel Magon and Sisto Luciani and Tiago Camargo Berti},
  journal={Chemioterapia : international journal of the Mediterranean Society of Chemotherapy},
  year={1986},
  volume={5 4},
  pages={
          219-27
        }
}
We investigated the action of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) in vitro on murine (3T3) and baby hamster kidney (BHK) fibroblasts and an in vivo highly metastatic subline of murine B16 melanoma (F10). CPDS determined an inhibition of cell growth and a decrease in cell adhesion, while 6-MNA had no effect. When combined with data of the mitotic index and endogenous purine ribonucleotides (on which the drugs seem to have no effect), these… CONTINUE READING