Effects of 5-methoxy-N,N-dimethyltryptamine on behavior and raphe unit activity in freely moving cats.

@article{Trulson1979EffectsO5,
  title={Effects of 5-methoxy-N,N-dimethyltryptamine on behavior and raphe unit activity in freely moving cats.},
  author={M. Trulson and B. Jacobs},
  journal={European journal of pharmacology},
  year={1979},
  volume={54 1-2},
  pages={
          43-50
        }
}
5-methoxy-N,N-dimethyltryptamine (5-MeODMT) produced a dose-dependent decrease in the discharge rate of serotonin-containing neurons in the dorsal raphe nucleus of freely moving cats. This ranged from a 15% decrease at 10 microgran/kg, i.m., to a virtual complete depression of activity at 250 microgram/kg. 5-MeODMT's effects on raphe units occurred with a very short latency (3-5 min) and its duration of action was dose-dependent and limited to an hour or less. The degree of depression of raphe… Expand
Raphe unit activity in freely moving cats: Effects of quipazine
Serotonin autoreceptors on dorsal raphe neurons: structure-activity relationships of tryptamine analogs
  • MA Rogawaski, G. Aghajanian
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1981
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