Effects of 5-iminodaunorubicin on nucleoli of rats

  title={Effects of 5-iminodaunorubicin on nucleoli of rats},
  author={John A. Peters and Michael J Evans and Richard A. Jensen and Edward M. Acton},
  journal={Cancer Chemotherapy and Pharmacology},
We have confirmed that doxorubicin induces irreversible changes in the nucleolar ultrastructure of myocardial cells of rats. Similar changes were not caused by an equal dose of the synthetic analogue, 5-iminodaunomycin. These results combined with previous and current comparative tests with this analogue, doxorubicin, and daunomycin suggest that 5… CONTINUE READING