Effects of 5 alpha reductase inhibitors on androgen-dependent human prostatic carcinoma cells

@article{Festuccia2004EffectsO5,
  title={Effects of 5 alpha reductase inhibitors on androgen-dependent human prostatic carcinoma cells},
  author={Claudio Festuccia and Adriano Angelucci and Giovanni Luca Gravina and Paola Muzi and Carlo Vicentini and M. Bologna},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2004},
  volume={131},
  pages={243-254}
}
To investigate the effects of MK906, a selective 5 alpha reductase (5αR) type 2 (5αR2) inhibitor, and of MK386, a specific 5αR1 inhibitor, on the cellular proliferation of androgen-dependent human prostatic cancer (PCa) cells in cultures of cells derived from bioptic and surgical tissues. In this study we tested the effects of MK906 and MK386 in 30 cultures derived from PCa, 6 from PIN and 10 from benign prostatic hyperplasia specimens. Prostate primary cultures under short-term conditions… CONTINUE READING

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Considering that 5αR1 ( responsible primarily for androgenic catabolism ) is mostly expressed in epithelial cells and that 5αR2 ( responsible for local DHT synthesis and release ) is expressed in the stromal cells ( which provides several paracrine growth factors and DHT itself to the epithelial cells ) , our experiments suggest that the inhibition of both 5αR1 and 5αR2 by MK386 and MK906 , respectively , may have therapeutic potential in order to reduce the growth and progression of human prostatic cancers , through the inhibition of autocrine or paracrine mechanisms involving the stromal cell compartment .
Considering that 5αR1 ( responsible primarily for androgenic catabolism ) is mostly expressed in epithelial cells and that 5αR2 ( responsible for local DHT synthesis and release ) is expressed in the stromal cells ( which provides several paracrine growth factors and DHT itself to the epithelial cells ) , our experiments suggest that the inhibition of both 5αR1 and 5αR2 by MK386 and MK906 , respectively , may have therapeutic potential in order to reduce the growth and progression of human prostatic cancers , through the inhibition of autocrine or paracrine mechanisms involving the stromal cell compartment .
Prostate carcinomaAssociated with malfunction of gene productTestosterone 5-alpha-Reductase
Effects of 5 alpha reductase inhibitors on androgen - dependent human prostatic carcinoma cells .
Effects of 5 alpha reductase inhibitors on androgen - dependent human prostatic carcinoma cells .
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