Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation
@article{Gur2013EffectsO5, title={Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation}, author={Serap Gur and Philip J. Kadowitz and Wayne J. G. Hellstrom}, journal={Expert Opinion on Drug Safety}, year={2013}, volume={12}, pages={81 - 90} }
Introduction: Treatment with 5-alpha reductase inhibitors (5ARI) is commonly utilized for the treatment of benign prostatic hyperplasia (BPH). The true prevalence of sexual side effects with 5ARI treatment is currently unknown. Areas covered: The current article reviews the reported adverse effects of 5ARI in regard to erectile function, sexual desire and ejaculation. A PubMed search was performed of all articles from 1990 to present, which reported any sexual side effects with finasteride or…
75 Citations
Sexual Dysfunction Related to Drugs : A Critical
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- 2014
A critical review of the current literature on sexual dysfunction caused by α-blocker and 5-ARI drugs and the use of phosphodiesterase type 5 (PDE5) inhibitors in combination with these drugs to identify possible intervention strategies for sexual dysfunction related to these drugs.
Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia
- MedicineThe world journal of men's health
- 2019
There is no evidence showing that adverse events of sexual dysfunction are absolutely associated with 5α-RIs, but physicians should discuss with their patients possible long-term effects of finasteride on sexual function, although there is not enough evidence to prove the relationship between finasterid and ED.
Adverse Effects of Pharmacological Therapy of Benign Prostatic Hyperplasia on Sexual Function in Men.
- Medicine, PsychologySrpski arhiv za celokupno lekarstvo
- 2015
Pharmacological therapy of BPH improved voiding symptoms producing different effects on male sexual function and the main adverse effect on sexual function in men is the deterioration in ejaculation or the absence thereof.
Sexual dysfunction in subjects treated with inhibitors of 5α‐reductase for benign prostatic hyperplasia: a comprehensive review and meta‐analysis
- MedicineAndrology
- 2017
The present data show that the use of 5ARI significantly increases the risk of erectile dysfunction and hypoactive sexual desire in subjects with benign prostatic hyperplasia and patients should be adequately informed before 5ARIs are prescribed.
The Impact of the 5α-Reductase Inhibitors (5α-RIs) on Male Sexual Function and Psychological Well-Being
- Medicine, PsychologyCurrent Sexual Health Reports
- 2015
It is imperative that clinicians give serious considerations to these adverse effects and their impact on patients’ health and engage their patients in an open and honest discussion regarding the potential harm of these agents prior to prescribing them.
Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs.
- Medicine, BiologyPharmacopsychiatry
- 2016
A critical review of the current literature to identify possible intervention strategies for sexual dysfunction related to α-blocker and 5-ARI drugs and the use of phosphodiesterase type 5 (PDE5) inhibitors in combination with these drugs.
Sexual Dysfunctions Related to Drugs Used in the Management of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Narrative Review on α-Blockers and 5-Alpha Reductase Inhibitors
- Biology, MedicineUro
- 2021
A critical review of the current literature data about sexual dysfunction as a potential side effect related to drugs commonly used for the treatment of Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms finds that silodosin appears to have the highest incidence of ejaculatory disorders.
Finasteride, not tamsulosin, increases severity of erectile dysfunction and decreases testosterone levels in men with benign prostatic hyperplasia
- MedicineHormone molecular biology and clinical investigation
- 2015
In men with BPH, long-term finasteride therapy but not tamsulosin results in worsening of ED and reduces total T concentrations, contributing to a state of hypogonadism.
Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects
- MedicineExpert opinion on pharmacotherapy
- 2020
Current evidence support the safety of 5-ARI on bone tissue, and due to the benefits of erection, PDE5i represents the perfect class of drugs for the treatment of LUTS-BPH in patients with erectile dysfunction.
Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function
- MedicineCurrent Urology Reports
- 2014
This review will delineate the currently known effects of these medications on sexual function and will consider mechanisms of dysfunction.
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