Effects of 5-HT4 Receptor Agonists and Antagonists in Learning

  title={Effects of 5-HT4 Receptor Agonists and Antagonists in Learning},
  author={Alfredo Meneses and Enrique Hong},
  journal={Pharmacology Biochemistry and Behavior},
  • A. MenesesE. Hong
  • Published 1 March 1997
  • Biology, Psychology
  • Pharmacology Biochemistry and Behavior

Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in learning

Short communication Role of 5-HT 1B , 5-HT 2A and 5-HT 2C receptors in learning

The present data suggest that both 5-HT1B and 4-HT2A‐2C receptors play a significant role in the consolidation of learning and the effects of mCPP most probably reflect activation of postsynaptic receptors.

The modulatory effect of CA1 5HT 4 receptors on memory acquisition deficit induced by harmaline

The results demonstrated that the synergistic effect between both CA1 5-HT4 receptor agonist and antagonist with impairment of memory acquisition induced by harmaline, indicating a modulatory effect for CA 1 5HT4 receptors on Harmaline induced amnesia.

A pharmacological analysis of serotonergic receptors: Effects of their activation of blockade in learning

  • A. MenesesE. Hong
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1997

Multiple 5-HT Receptors in Passive Avoidance: Comparative Studies of p-Chloroamphetamine and 8-OH-DPAT

BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse

The ability of 5-HT4 receptor agonists to reverse spontaneous working memory deficits is demonstrated and the therapeutic potential of such ligands in the treatment of cognitive alterations that associate short-term working memory disorders and cholinergic hypofunction is confirmed.



Mechanism of action of 8-OH-DPAT on learning and memory

Effect of fluoxetine on learning and memory involves multiple 5-HT systems

Serotonergic regulation of associative learning

  • J. Harvey
  • Biology, Psychology
    Behavioural Brain Research
  • 1995

The psychopharmacology of 5-HT3 receptors.

5-Hydroxytryptamine4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus.

Clear differences are established between the 5-HT receptor(s) mediating the depolarization and reduction in the afterhyperpolarization in the hippocampus and the5-HT3 and 5- HT1p receptors and its classification in the 5 -HT4 class is suggested.

Effects of 5-HT3 receptor antagonism on hippocampal theta rhythm, memory, and LTP induction in the freely moving rat

  • U. StaubliF. Xu
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
Ondansetron, a potent and selective antagonist of the 5- HT3 receptor, was examined on frequency of the hippocampal theta rhythm, induction of LTP in field CA1 of freely moving rats, and retention of olfactory and spatial memory in tasks known to depend on an intact hippocampus.